Publications
22 results
22 results
2016
Shimada K, Hayano M, Pagano N, Stockwell B. Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity. Cell Chem Biol. 2016;23(2):225–35. doi:10.1016/j.chembiol.2015.11.016
Shimada K, Hayano M, Pagano N, Stockwell B. Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity. Cell Chem Biol. 2016;23(2):225–35. doi:10.1016/j.chembiol.2015.11.016
2014
Julien O, Kampmann M, Bassik M, Zorn J, Venditto V, Shimbo K, Agard N, Shimada K, Rheingold A, Stockwell B, et al. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014;10(11):969–76. doi:10.1038/nchembio.1639
Julien O, Kampmann M, Bassik M, Zorn J, Venditto V, Shimbo K, Agard N, Shimada K, Rheingold A, Stockwell B, et al. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014;10(11):969–76. doi:10.1038/nchembio.1639
Skouta R, Dixon S, Wang J, Dunn D, Orman M, Shimada K, Rosenberg P, Lo D, Weinberg J, Linkermann A, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551–6. doi:10.1021/ja411006a
Skouta R, Dixon S, Wang J, Dunn D, Orman M, Shimada K, Rosenberg P, Lo D, Weinberg J, Linkermann A, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551–6. doi:10.1021/ja411006a
Yang WS, SriRamaratnam R, Welsch M, Shimada K, Skouta R, Viswanathan V, Cheah J, Clemons P, Shamji A, Clish C, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1-2):317–31. doi:10.1016/j.cell.2013.12.010
Yang WS, SriRamaratnam R, Welsch M, Shimada K, Skouta R, Viswanathan V, Cheah J, Clemons P, Shamji A, Clish C, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1-2):317–31. doi:10.1016/j.cell.2013.12.010
2012
Skouta R, Hayano M, Shimada K, Stockwell B. Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death. Bioorg Med Chem Lett. 2012;22(17):5707–13. doi:10.1016/j.bmcl.2012.06.077
Skouta R, Hayano M, Shimada K, Stockwell B. Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death. Bioorg Med Chem Lett. 2012;22(17):5707–13. doi:10.1016/j.bmcl.2012.06.077
Weïwer M, Bittker J, Lewis T, Shimada K, Yang WS, MacPherson L, Dandapani S, Palmer M, Stockwell B, Schreiber S, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012;22(4):1822–6. doi:10.1016/j.bmcl.2011.09.047
Weïwer M, Bittker J, Lewis T, Shimada K, Yang WS, MacPherson L, Dandapani S, Palmer M, Stockwell B, Schreiber S, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012;22(4):1822–6. doi:10.1016/j.bmcl.2011.09.047
Yang WS, Shimada K, Delva D, Patel M, Ode E, Skouta R, Stockwell B. Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency. ACS Med Chem Lett. 2012;3(1):35–38. doi:10.1021/ml200195s
Yang WS, Shimada K, Delva D, Patel M, Ode E, Skouta R, Stockwell B. Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency. ACS Med Chem Lett. 2012;3(1):35–38. doi:10.1021/ml200195s
2011
Herman A, Hayano M, Poyurovsky M, Shimada K, Skouta R, Prives C, Stockwell B. Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov. 2011;1(4):312–25. doi:10.1158/2159-8290.CD-11-0104
Herman A, Hayano M, Poyurovsky M, Shimada K, Skouta R, Prives C, Stockwell B. Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discov. 2011;1(4):312–25. doi:10.1158/2159-8290.CD-11-0104
Wolpaw A, Shimada K, Skouta R, Welsch M, Akavia UD, Pe’er D, Shaik F, Bulinski C, Stockwell B. Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proc Natl Acad Sci U S A. 2011;108(39):E771–80. doi:10.1073/pnas.1106149108
Wolpaw A, Shimada K, Skouta R, Welsch M, Akavia UD, Pe’er D, Shaik F, Bulinski C, Stockwell B. Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proc Natl Acad Sci U S A. 2011;108(39):E771–80. doi:10.1073/pnas.1106149108
2010
Shiozuka M, Wagatsuma A, Kawamoto T, Sasaki H, Shimada K, Takahashi Y, Nonomura Y, Matsuda R. Transdermal delivery of a readthrough-inducing drug: a new approach of gentamicin administration for the treatment of nonsense mutation-mediated disorders. J Biochem. 2010;147(4):463–70. doi:10.1093/jb/mvp185
Shiozuka M, Wagatsuma A, Kawamoto T, Sasaki H, Shimada K, Takahashi Y, Nonomura Y, Matsuda R. Transdermal delivery of a readthrough-inducing drug: a new approach of gentamicin administration for the treatment of nonsense mutation-mediated disorders. J Biochem. 2010;147(4):463–70. doi:10.1093/jb/mvp185