Kenichi Shimada

To deliver effective cancer therapy for more patients

Kenichi Shimada

Kenichi Shimada is a Research Associate in the Laboratory of Systems Pharmacology at Harvard Medical School (HMS) and has a joint appointment at the Ludwig Center and at the Guerriero Laboratory at Brigham and Women's Hospital. He has a background in both experimental and computational biology. Kenichi received his Ph.D. for the elucidation of the mechanisms of ferroptosis, a form of non-apoptotic cell death phenotype, under the supervision of Dr. Brent Stockwell at Columbia Univeristy. In 2015, he came to HMS and continued his training as a postdoctoral fellow with Dr. Timothy Mitchison and has published a few papers in mechanistic toxicology and cancer signaling.

Since December 2020, Kenichi started to work with Drs. Jennifer GuerrieroJoan Brugge, and Peter Sorger to elucidate tumor-intrinsic and extrinsic factors that predict clinical outcomes in breast cancer cohorts using single-cell transcriptome and multi-dimensional imaging.

Recent Publications

2025

Wanderley CWS, Michaud DE, Shimada K, Nelson A, Fu J, Schnitt SJ, Tolaney SM, Mittendorf EA, Barroso-Sousa R, Waks A, et al. APOE+ Tumor-Associated Macrophages and CD4-DOCK4 T Cells Reveal Distinct Microenvironmental Features in HER2-Low and HER2-0 Hormone Receptor-Positive Breast Cancer. bioRxiv. 2025.
Wanderley CWS, Michaud DE, Shimada K, Nelson A, Fu J, Schnitt SJ, Tolaney SM, Mittendorf EA, Barroso-Sousa R, Waks A, et al. APOE+ Tumor-Associated Macrophages and CD4-DOCK4 T Cells Reveal Distinct Microenvironmental Features in HER2-Low and HER2-0 Hormone Receptor-Positive Breast Cancer. bioRxiv. 2025.

2024

Guerriero JL, Lin J-R, Pastorello R, Du Z, Chen Y-A, Townsend MG, Shimada K, Hughes ME, Ren S, Tayob N, et al. Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer. NPJ Breast Cancer. 2024;10(1).
Guerriero JL, Lin J-R, Pastorello R, Du Z, Chen Y-A, Townsend MG, Shimada K, Hughes ME, Ren S, Tayob N, et al. Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer. NPJ Breast Cancer. 2024;10(1).
Shimada K, Michaud DE, Cui YX, Zheng K, Goldberg J, Ju Z, Schnitt SJ, Pastorello R, Kania LD, Hoffer J, et al. An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer. bioRxiv. 2024.
Shimada K, Michaud DE, Cui YX, Zheng K, Goldberg J, Ju Z, Schnitt SJ, Pastorello R, Kania LD, Hoffer J, et al. An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer. bioRxiv. 2024.

2021

Weng J-H, Koch PD, Luan H, Tu H-C, Shimada K, Ngan I, Ventura R, Jiang R, Mitchison T. Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation. Nat Metab. 2021;3(4):513–522. doi:10.1038/s42255-021-00366-y
Weng J-H, Koch PD, Luan H, Tu H-C, Shimada K, Ngan I, Ventura R, Jiang R, Mitchison T. Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation. Nat Metab. 2021;3(4):513–522. doi:10.1038/s42255-021-00366-y
Shimada K, Bachman J, Muhlich J, Mitchison T. shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data. Elife. 2021;10. doi:10.7554/eLife.57116
Shimada K, Bachman J, Muhlich J, Mitchison T. shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data. Elife. 2021;10. doi:10.7554/eLife.57116

2020

Stokes M, Small JC, Vasciaveo A, Shimada K, Hirschhorn T, Califano A, Stockwell B. Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation. Sci Rep. 2020;10(1):10748. doi:10.1038/s41598-020-67310-0
Stokes M, Small JC, Vasciaveo A, Shimada K, Hirschhorn T, Califano A, Stockwell B. Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation. Sci Rep. 2020;10(1):10748. doi:10.1038/s41598-020-67310-0